{"id":1046,"date":"2025-04-29T13:56:39","date_gmt":"2025-04-29T12:56:39","guid":{"rendered":"https:\/\/www.donatural.com\/?post_type=raziskuj&p=1046"},"modified":"2025-05-19T09:00:59","modified_gmt":"2025-05-19T08:00:59","slug":"znanost-iza-postbiotika-bifidobacteriumlongum-ht-es1","status":"publish","type":"raziskuj","link":"https:\/\/www.donatural.com\/hr\/istrazuj\/znanost-iza-postbiotika-bifidobacteriumlongum-ht-es1\/","title":{"rendered":"Znanost iza postbiotika Bifidobacteriumlongum HT – ES1"},"content":{"rendered":"\n

U svijetu mikrobioma postbiotici se pojavljuju kao nova nada za unaprje\u0111enje zdravlja, nude\u0107i brojne potencijalne koristi za crijeva, imunolo\u0161ki sustav i op\u0107e blagostanje.<\/p>\n\n\n\n

Iako su istra\u017eivanja o postbioticima jo\u0161 uvijek u tijeku, preliminarni rezultati upu\u0107uju na mogu\u0107e koristi kod upalnih bolesti crijeva, proljeva, alergija, pretilosti i metaboli\u010dkog sindroma, ali i sindroma iritabilnog crijeva.<\/p>\n\n\n\n

IBS je kroni\u010dni funkcionalni gastrointestinalni poreme\u0107aj <\/strong>koji <\/strong>karakterizira<\/strong>ju<\/strong> bolovi u trbuhu, naduto<\/strong>st<\/strong> i abnormalnosti u u\u010destalosti ili obliku stolice<\/strong>(1)<\/strong>.<\/strong>Globalna prevalencija IBS-a procjenjuje se na 11,2%, sa stopama od 5% do 15% zabilje\u017eenim u ve\u0107ini europskih zemalja (4).<\/p>\n\n\n\n

Simptomi mogu biti iscrpljuju\u0107i i zna\u010dajno utjecati na kvalitetu \u017eivota (2). Probavna mikrobiota ljudi koji \u017eive s IBS-om znatno se razlikuje od mikrobiote zdravih pojedinaca. Probavna mikrobiota mo\u017ee igrati klju\u010dnu ulogu u etiologiji IBS-a, a simptomi IBS-a mogu se ubla\u017eiti modulacijom crijevne mikrobiote. IBS je multifaktorski poreme\u0107aj, a njegova slo\u017eena patofiziologija jo\u0161 uvijek nije u potpunosti razja\u0161njena. Znanstvenici smatraju da su promijenjena visceralna osjetljivost, motilitet crijeva i sekretorne disfunkcije uz strukturne abnormalnosti, kao \u0161to je mikrobna neravnote\u017ea, \u010dimbenici koji doprinose patofiziologiji IBS-a (3).<\/p>\n\n\n\n

U travnju 2024.<\/strong>godine<\/strong> objavljena je vrlo zna\u010dajna klini\u010dka studija koja je pokazala obe\u0107avaju\u0107e rezultate na podru\u010dju sindroma iritabilnog crijeva i <\/strong>postbiotika<\/strong>.<\/strong><\/p>\n\n\n\n

Cilj studije bio je utvrditi u\u010dinkovitost <\/strong>probioti\u010dkog<\/strong> soja <\/strong>Bifidobacterium<\/strong><\/em>longum<\/strong><\/em> ES1 i <\/strong>postbioti\u010dkog<\/strong> soja <\/strong>Bifidobacterium<\/strong><\/em>lon<\/strong><\/em>gum<\/strong> HT-ES1 u pobolj\u0161anju gastrointestinalnih simptoma kod sudionika sa sindromom iritabilnog crijeva s predominantnom dijarejom.<\/strong><\/p>\n\n\n\n

Pokazalo se da je kori\u0161tenje 1 x109<\/sup>CFU\/dan ES1 i 2,5 x 109<\/sup> stanica\/dan HT-ES1 u\u010dinkovito u smanjenju te\u017eine simptoma IBS-a, mjereno s<\/strong>ustav<\/strong>om<\/strong> za bodovanje te\u017eine simptoma sindroma iritabilnog crijeva<\/strong>. Upitnik se sastoji od pet pitanja koja se odnose na ja\u010dinu bolova u trbuhu, u\u010destalost bolova u trbuhu, ja\u010dinu nadutosti trbuha, zadovoljstvo navikama pra\u017enjenja crijeva i utjecaj simptoma na op\u0107u kvalitetu \u017eivota.<\/p>\n\n\n\n

Rezultati studije pokazali su obe\u0107avaju\u0107e rezultate. Do\u0161lo je i do pobolj\u0161anja u konzistenciji stolice, kvaliteti \u017eivota, ja\u010dini boli u trbuhu i anksioznosti, u usporedbi s placebom tijekom 12-tjednog razdoblja intervencije.<\/p>\n\n\n\n

Rezultati ove studije zna\u010dajno pridonose polju istra\u017eivanja IBS-a, prvo pru\u017eanjem klini\u010dki zna\u010dajnih i statisti\u010dki zna\u010dajnih rezultata iz rigoroznog, dobro osmi\u0161ljenog randomiziranog, placebom kontroliranog ispitivanja i sli\u010dno, istra\u017eivanjem upotrebe postbiotika u IBS-u, podru\u010dju istra\u017eivanja koje je jo\u0161 u povojima. Suplementacija <\/strong>probioticima<\/strong> (ES1) i <\/strong>postbioticima<\/strong> (HT-ES1) zna\u010dajno je smanjila ocjene te\u017eine simptoma IBS-a u usporedbi s placebom.<\/strong> Ova studija postigla je primarne i sekundarne rezultate i sna\u017eno sugerira da bi ES1 i HT-ES1 mogli biti korisni u lije\u010denju IBS-a.<\/p>\n\n\n\n

Izvori:<\/p>\n\n\n\n

    \n
  1. Saha<\/strong> L. <\/strong>Irritable<\/strong>bowel<\/strong>syndrome<\/strong>: <\/strong>pathogenesis<\/strong>, <\/strong>diagnosis<\/strong>, <\/strong>treatment<\/strong>, <\/strong>and<\/strong>evidence-based<\/strong> medicine. World J <\/strong>Gastroenterol<\/strong>. 2014;20(22):6759\u201315.<\/strong><\/li>\n\n\n\n
  2. Buono<\/strong> JL, Carson RT, <\/strong>Flores<\/strong> NM. Health-<\/strong>related<\/strong>quality<\/strong>of<\/strong>life<\/strong>, <\/strong>work<\/strong>productivity<\/strong>, <\/strong>and<\/strong>indirect<\/strong>costs<\/strong>among<\/strong>patients<\/strong>with<\/strong>irritable<\/strong>bowel<\/strong>syndrome<\/strong>with<\/strong>diarrhea<\/strong>. Health <\/strong>Qual<\/strong> Life <\/strong>Outcomes<\/strong>. 2017;15(1):35. doi:10.1186\/s12955-017-0611-2<\/strong><\/li>\n\n\n\n
  3. Ford AC, <\/strong>Lacy<\/strong> BE, <\/strong>Talley<\/strong> NJ, <\/strong>Longo<\/strong> DL. <\/strong>Irritable<\/strong>bowel<\/strong>syndrome<\/strong>. N <\/strong>Engl<\/strong> J Med. 2017;376(26):2566\u20132578. doi:10.1056\/NEJMra1607547<\/strong><\/li>\n\n\n\n
  4. Lovell<\/strong> RM, Ford AC. Global <\/strong>prevalence<\/strong>of<\/strong>and<\/strong>risk<\/strong>factors<\/strong> for <\/strong>irritable<\/strong>bowel<\/strong>syndrome<\/strong>: a meta-<\/strong>analysis<\/strong>. <\/strong>Clin<\/strong>Gastroenterol<\/strong>Hepatol<\/strong>. 2012;10(7):712\u201321.e4. doi:10.1016\/j.cgh.2012.02.029<\/strong><\/li>\n\n\n\n
  5. Srivastava<\/em>, S., <\/em>Basak<\/em>, U., <\/em>Naghibi<\/em>, M., <\/em>Vijayakumar<\/em>, V., <\/em>Parihar<\/em>, R., <\/em>Patel<\/em>, J., <\/em>Jadon<\/em>, P. S., <\/em>Pandit<\/em>, A., <\/em>Dargad<\/em>, R. R., <\/em>Khanna<\/em>, S., Kumar, S., & Day, R. (2024). A <\/em>randomized<\/em>double-blind<\/em>, placebo-<\/em>controlled<\/em>trial<\/em> to <\/em>evaluate<\/em>the<\/em>safety<\/em>and<\/em>efficacy<\/em>of<\/em> live <\/em>Bifidobacterium<\/em>longum<\/em> CECT 7347 (ES1) <\/em>and<\/em>heat-treated<\/em>Bifidobacterium<\/em>longum<\/em> CECT 7347 (HT-ES1) <\/em>in<\/em>participants<\/em>with<\/em>diarrhea-predominant<\/em>irritable<\/em>bowel<\/em>syndrome<\/em>. <\/em>Gut<\/em>microbes<\/em>, 16(1), 2338322. <\/em>https:\/\/doi.org\/10.1080\/19490976.2024.2338322<\/em><\/u><\/a><\/li>\n<\/ol>\n\n\n\n

    <\/p>\n","protected":false},"excerpt":{"rendered":"

    U svijetu mikrobioma postbiotici se pojavljuju kao nova nada za unaprje\u0111enje zdravlja, nude\u0107i brojne potencijalne koristi za crijeva, imunolo\u0161ki sustav i op\u0107e blagostanje. Iako su istra\u017eivanja o postbioticima jo\u0161 uvijek u tijeku, preliminarni rezultati upu\u0107uju na mogu\u0107e koristi kod upalnih bolesti crijeva, proljeva, alergija, pretilosti i metaboli\u010dkog sindroma, ali i sindroma iritabilnog crijeva. IBS je kroni\u010dni …<\/a><\/p>\n","protected":false},"author":4,"featured_media":1800,"menu_order":0,"template":"","category_blog":[32,35],"class_list":["post-1046","raziskuj","type-raziskuj","status-publish","has-post-thumbnail","hentry","category_blog-biotici","category_blog-osovina-crijevo-mozak"],"acf":[],"yoast_head":"\nZnanost iza postbiotika Bifidobacteriumlongum HT - ES1 - Donatural<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.donatural.com\/hr\/istrazuj\/znanost-iza-postbiotika-bifidobacteriumlongum-ht-es1\/\" \/>\n<meta property=\"og:locale\" content=\"hr_HR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Znanost iza postbiotika Bifidobacteriumlongum HT - ES1 - Donatural\" \/>\n<meta property=\"og:description\" content=\"U svijetu mikrobioma postbiotici se pojavljuju kao nova nada za unaprje\u0111enje zdravlja, nude\u0107i brojne potencijalne koristi za crijeva, imunolo\u0161ki sustav i op\u0107e blagostanje. Iako su istra\u017eivanja o postbioticima jo\u0161 uvijek u tijeku, preliminarni rezultati upu\u0107uju na mogu\u0107e koristi kod upalnih bolesti crijeva, proljeva, alergija, pretilosti i metaboli\u010dkog sindroma, ali i sindroma iritabilnog crijeva. 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