{"id":868,"date":"2025-04-29T13:56:39","date_gmt":"2025-04-29T12:56:39","guid":{"rendered":"https:\/\/www.donatural.com\/?post_type=raziskuj&p=868"},"modified":"2026-03-04T13:44:10","modified_gmt":"2026-03-04T12:44:10","slug":"znanstveno-ozadje-postbiotikov-bifidobacterium-longum-ht-es1","status":"publish","type":"raziskuj","link":"https:\/\/www.donatural.com\/sl\/raziskuj\/znanstveno-ozadje-postbiotikov-bifidobacterium-longum-ht-es1\/","title":{"rendered":"Znanstveno ozadje postbiotikov Bifidobacterium longum HT-ES1"},"content":{"rendered":"\n

Na podro\u010dju mikrobioma se postbiotiki ka\u017eejo kot novo upanje za izbolj\u0161anje zdravja, saj imajo \u0161tevilne potencialne koristi za \u010drevesje, imunski sistem in splo\u0161no dobro po\u010dutje.<\/p>\n\n\n\n

\u010ceprav raziskave o postbiotikih \u0161e potekajo, prvi rezultati ka\u017eejo na morebitne koristi pri vnetnih \u010drevesnih boleznih, driski, alergijah, debelosti in presnovnem sindromu ter sindromu razdra\u017eljivega \u010drevesja (IBS).<\/p>\n\n\n\n

IBS je kroni\u010dna funkcionalna gastrointestinalna motnja, za katero so zna\u010dilne bole\u010dine v trebuhu, napenjanje in motnje v pogostosti iztrebljanja ali obliki blata (1). <\/strong>Svetovna raz\u0161irjenost IBS je ocenjena na 11,2 %, v ve\u010dini evropskih dr\u017eav pa je od 5 do 15 % (4).<\/p>\n\n\n\n

Simptomi so lahko zelo obremenjujo\u010di in bistveno vplivajo na kakovost \u017eivljenja (2). Prebavna mikrobiota pri ljudeh z IBS se bistveno razlikuje od mikrobiote pri zdravih posameznikih. Prebavna mikrobiota ima lahko klju\u010dno vlogo pri etiologiji IBS, simptome te motnje pa je mogo\u010de ubla\u017eiti z modulacijo \u010drevesne mikrobiote. IBS je ve\u010dfaktorska motnja in njena zapletena patofiziologija \u0161e vedno ni povsem pojasnjena. Znanstveniki menijo, da k patofiziologiji IBS prispevajo spremenjena visceralna ob\u010dutljivost, gibljivost \u010drevesja in motnje izlo\u010danja, pa tudi strukturne nepravilnosti, kot je poru\u0161eno mikrobno ravnovesje (3).<\/p>\n\n\n\n

Aprila 2024 je bila objavljena zelo pomembna klini\u010dna \u0161tudija, ki je pokazala obetavne rezultate na podro\u010dju sindroma razdra\u017eljivega \u010drevesja in postbiotikov.<\/strong><\/p>\n\n\n\n

Cilj \u0161tudije je bil ugotoviti u\u010dinkovitost probioti\u010dnega seva <\/strong>Bifidobacterium longum<\/strong><\/em> ES1 in postbioti\u010dnega seva <\/strong>Bifidobacterium longum<\/strong><\/em> HT-ES1 pri izbolj\u0161anju gastrointestinalnih simptomov med osebami s sindromom razdra\u017eljivega \u010drevesja s predominantno drisko.<\/strong><\/p>\n\n\n\n

Izkazalo se je, da je uporaba ES1 1 x 109 <\/sup>CFU\/dan in HT-ES1 2,5 x 109<\/sup> celic\/dan u\u010dinkovita pri zmanj\u0161evanju intenzivnosti simptomov IBS, merjenih s sistemom za ocenjevanje resnosti simptomov sindroma razdra\u017eljivega \u010drevesja<\/strong>. Vpra\u0161alnik sestavlja pet vpra\u0161anj o intenzivnosti bole\u010din v trebuhu, pogostosti bole\u010din v trebuhu, intenzivnosti napenjanja trebuha, zadovoljstvu z navadami iztrebljanja in vplivu simptomov na splo\u0161no kakovost \u017eivljenja.<\/p>\n\n\n\n

Rezultati \u0161tudije so obetavni. V primerjavi s placebom so se v 12-tedenskem intervencijskem obdobju izbolj\u0161ali tudi konsistenca blata, kakovost \u017eivljenja, intenzivnost bole\u010din v trebuhu in anksioznost.<\/p>\n\n\n\n

Rezultati te \u0161tudije so pomemben prispevek na podro\u010dju raziskav IBS, saj zagotavljajo klini\u010dno uporabne in statisti\u010dno pomembne rezultate, pridobljene z natan\u010dno, dobro na\u010drtovano in randomizirano ter s placebom nadzorovano \u0161tudijo, poleg tega pa obravnavajo uporabo postbiotikov pri zdravljenju IBS, kar je podro\u010dje raziskav, ki je \u0161e vedno v povojih. Uporaba prehranskih dopolnil s probiotiki (ES1) in postbiotiki (HT-ES1) je v primerjavi s placebom pomembno vplivala na zmanj\u0161anje ocene resnosti simptomov IBS.<\/strong> \u0160tudija je dosegla primarne in sekundarne rezultate ter jasno ka\u017ee, da sta ES1 in HT-ES1 lahko uporabna pri zdravljenju IBS.<\/p>\n\n\n\n

Viri:<\/p>\n\n\n\n

    \n
  1. Saha L. Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine.\u00a0World J Gastroenterol. 2014;20(22):6759\u201315.<\/strong><\/li>\n\n\n\n
  2. Buono JL, Carson RT, Flores NM. Health-related quality of life, work productivity, and indirect costs among patients with irritable bowel syndrome with diarrhea.\u00a0Health Qual Life Outcomes. 2017;15(1):35. doi:10.1186\/s12955-017-0611-2<\/strong><\/li>\n\n\n\n
  3. Ford AC, Lacy BE, Talley NJ, Longo DL. Irritable bowel syndrome.\u00a0N Engl J Med. 2017;376(26):2566\u20132578. doi:10.1056\/NEJMra1607547<\/strong><\/li>\n\n\n\n
  4. Lovell RM, Ford AC. Global prevalence of and risk factors for irritable bowel syndrome: a meta-analysis.\u00a0Clin Gastroenterol Hepatol. 2012;10(7):712\u201321.e4. doi:10.1016\/j.cgh.2012.02.029<\/strong><\/li>\n\n\n\n
  5. Srivastava, S., Basak, U., Naghibi, M., Vijayakumar, V., Parihar, R., Patel, J., Jadon, P. S., Pandit, A., Dargad, R. R., Khanna, S., Kumar, S., & Day, R. (2024). A randomized double-blind, placebo-c<\/em>ontrolled trial to evaluate the safety and efficacy of live Bifidobacterium longum CECT 7347 (ES1) and heat-treated Bifidobacterium longum CECT 7347 (HT-ES1) in participants with diarrhea-predominant irritable bowel syndrome. Gut microbes, 16(1), 2338322. <\/em>https:\/\/doi.org\/10.1080\/19490976.2024.2338322<\/em><\/u><\/a><\/li>\n<\/ol>\n","protected":false},"excerpt":{"rendered":"

    Na podro\u010dju mikrobioma se postbiotiki ka\u017eejo kot novo upanje za izbolj\u0161anje zdravja, saj imajo \u0161tevilne potencialne koristi za \u010drevesje, imunski sistem in splo\u0161no dobro po\u010dutje. \u010ceprav raziskave o postbiotikih \u0161e potekajo, prvi rezultati ka\u017eejo na morebitne koristi pri vnetnih \u010drevesnih boleznih, driski, alergijah, debelosti in presnovnem sindromu ter sindromu razdra\u017eljivega \u010drevesja (IBS). IBS je kroni\u010dna …<\/a><\/p>\n","protected":false},"author":4,"featured_media":1798,"menu_order":0,"template":"","category_blog":[28],"class_list":["post-868","raziskuj","type-raziskuj","status-publish","has-post-thumbnail","hentry","category_blog-biotiki"],"acf":[],"yoast_head":"\nZnanstveno ozadje postbiotikov Bifidobacterium longum HT-ES1 - Donatural<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.donatural.com\/sl\/raziskuj\/znanstveno-ozadje-postbiotikov-bifidobacterium-longum-ht-es1\/\" \/>\n<meta property=\"og:locale\" content=\"sl_SI\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Znanstveno ozadje postbiotikov Bifidobacterium longum HT-ES1 - Donatural\" \/>\n<meta property=\"og:description\" content=\"Na podro\u010dju mikrobioma se postbiotiki ka\u017eejo kot novo upanje za izbolj\u0161anje zdravja, saj imajo \u0161tevilne potencialne koristi za \u010drevesje, imunski sistem in splo\u0161no dobro po\u010dutje. \u010ceprav raziskave o postbiotikih \u0161e potekajo, prvi rezultati ka\u017eejo na morebitne koristi pri vnetnih \u010drevesnih boleznih, driski, alergijah, debelosti in presnovnem sindromu ter sindromu razdra\u017eljivega \u010drevesja (IBS). 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